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KMID : 0605820090160010006
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Korean Journal of Pediatric Infectious Diseases
2009 Volume.16 No. 1 p.6 ~ p.11
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New Antimicrobial Agents for Children
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Eun Byung-Wook
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Abstract
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There are relatively few novel antimicrobial agents despite the dramatic increase in antimicrobial resistance and multiple
drug resistance of clinical isolates worldwide. Vancomycin is still the most widely used antibiotic for treating resistant
Gram-positive coccal infections in children, especially for methicillin-resistant Staphylococcus aureus. For children with
Gram-positive coccal infections where vancomycin is not effective or older therapeutic agents cannot be tolerated,
linezolid, quinupristin-dalfopristin or daptomycin may be useful in the appropriate clinical setting. For Gram-negative
bacterial infections, new carbapenems await clinical application. Tebipenem pivoxil is a novel oral carbapenem undergoing clinical trials for acute otitis media in pediatric patients. Antiviral drug development is now progressing at the pace of antibiotic development 30 years ago. Newer antiviral agents used for the treatment of herpes viruses and hepatitis
C virus infections in children are included in this review.
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KEYWORD
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Anti-Bacterial Agents, Antiviral Agents, Child
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